AIRWAY INFLAMMATION IN SEVERE NON–ALLERGIC EOSINOPHILIC ASTHMA

Abstract

Eosinophilic asthma is one of multiple phenotypes of asthma based on the eosinophil-rich inflammation in the airways. Severe eosinophilic asthma usually is non-allergic, associated with severe clinical course, late-onset disease, with frequent exacerbation and steroid refractoriness, not so rare with disability cases. Therefore, the focus on this asthma phenotype is not in vain: this may be related to insufficiently managed eosinophilic inflammation. The review provides generalized data on the mechanisms of airway non-allergic eosinophilic inflammation development, the importance of biological markers, the latest treatment options.