AGING CAUSED ASTHMA PATHOGENESIS CHANGES

Abstract

Aging is a natural part of human life that begins with birth and affect the entire body, including the respiratory tract. The age-related structural, physiological and immunological changes of the respiratory system may affect lung function and the clinical course of various respiratory diseases. Asthma is the one of the most common chronic respiratory diseases worldwide. The impact of aging on asthma is especially topical. The World Health Organization (WHO) reports that prevalence of asthma in the elderly increase rapidly; it is characterized by more severe disease course, increased resistance to treatment and worse outcomes. It is observed that there are similarities in structural lung changes between asthma (especially severe) pathogenesis and natural aging process in the lungs. In order to better understand the mechanisms of disease pathogenesis in the last decade it isgrowing interest in the main inflammatory cells interaction with structural airway cells. It is believed that staged airway remodeling processes blocking could slow down the progression of airway structural changes in asthma and lead to better treatment effect.