IMPORTANCE OF WNT SIGNALING PATHWAY IN ASTHMA PATHOGENESIS

Abstract

Wnt signaling pathway – it is secreted glicoproteins regulative pathway,
which can act to gene transcription, cytoplacmic changes, intracellular Ca2+ storages. Due to regulation of celullar processes, from embryonic development to apoptosis, Wnt signaling pathway maintain appropriate organism activity at cellular level. Wnt signaling pathway is important to normal lung development and various lung deseases pathogenesis. Asthmatic patients have increased Wnt ligands and transforming growth factors β1 expression, which induce airway remodeling. In this review we demonstrate importance of Wnt signaling pathway in lung deseases, especially in asthma pathogenesis.