PROGRESSION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: IMPACT OF INFLAMMATION AND THERAPEUTIC INTERVENTION

Abstract

Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. This multicomponent disease involves both airway and systemic inflammation at all stages and may influence the progression of disease. This article reviews evidence linking inflammation and COPD progression and the potential role of anti-inflammatory therapies. Better understanding of the specific inflammatory mechanisms underlying COPD disease progression will likely lead to more effective management of the disease.