CHRONIC URTICARIA

Abstract

Chronic urticaria negatively impacts quality of life via sleep disruption, fatigue, social isolaton, energy loss, and emotional/sexual difficulties. Chronic urticaria is heterogeneous group of deseases that share a distinct skin reaction – the development of urticarial skin lession. Wheals with or without angioedema appear and peak in minutes to hours, ussually disappear within 24 h and repeats for more than 6 weeks. Chronic idiopathic urticaria is the diagnosis when the pathophysiological mechanism of persistent urticaria remains unclear; up to half of patients with chronic idiopathic urticaria has functional autoantibodies, which appear to induce mast cell degranulation. But our as medical doctors main task is to find the real cause of urticaria. Systemic histamine H1 receptor antagonists are central to the management of chronic urticaria.